Nuclear lamins interact with inner nuclear membrane proteins to form the nuclear lamina on the interior of the nuclear envelope. During mitosis the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. 1 a type lamins which are generated by alternatively splicing of the lmna gene into lamin a and c and some less abundant isoforms and 2 b type lamins which are encoded by the lmnb1 and lmnb2 genes which produce lamin b1 and b2 b3 respectively.
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