Lamin Expression In Cancer

Lamin a tended to be lower in ovarian cancer and higher expression of lamin a was associated with better survival.

Lamin expression in cancer. Lamin a c alternative splice variants lamin a lamin c lamin aδ10 and lamin aδ50 have been implicated in cell cycle regulation dna replication transcription regulation cellular differentiation apoptosis and aging. We have examined the expression of lamins a b1 and c in human tissues and cancer cell lines and the function of the lamin a c and b1 gene promoters in transfected cells. Liver cancer78 pancreatic cancer46 lamin levels both lamin a c and lamin b change in cancers of various organs suggesting that lamins either play a role in cancer progression or alter in response to it. Even in lamin a c positive breast cancer lamin a c expression is heterogeneous or aberrant such as non nuclear distribution in the population of tumor cells as determined by immunohistology and immunofluorescence microscopy.

In addition loss of lamin a c expression has been observed in several cancers including breast cancer and it has been found that lamin a c suppression may. Northern analysis and immunoblotting demonstrated that lamin a c mrna and protein were not detectable in some human cell lines whereas lamin b1 was always present. In most breast cancer cell lines a significant fraction of the lamin a c negative population was observed. Arrows indicate decrease down or increase up of either gene or protein expression.

In 1997 and 2014 broers et al. Lamin a tended to be lower in ovarian cancer and higher expression of lamin a was associated with better survival. The finding that lamin a may be a putative stem cell biomarker has further implications for our discovery that expression of lamin a c in crc is closely correlated with an increased risk of crc related mortality since it could be considered feasible that cancer cells expressing lamin a may have a more stem cell like phenotype and therefore be. After lamin a knockdown 2d and 3d migration 3 μm 8 μm abilities of ho 8910 cells were significantly increased p 0 001 while overexpression of lamin a in ho 8910pm impeded migration.

After lamin a knockdown 2d and 3d migration 3 μm 8 μm abilities of ho 8910 cells were significantly increased p 0 001 while overexpression of lamin a in ho 8910pm impeded migration meanwhile when ho 8910 cells migrated through 3 μm pores nuclei became. Even in lamin a c positive breast cancer lamin a c expression is heterogeneous or aberrant such as non nuclear distribution in the population of tumor cells as determined by immunohistology and immunofluorescence microscopy. In addition loss of lamin a c expression has been observed in several cancers including breast cancer and it has been found that lamin a c suppression may lead to cancer like aberrations in nuclear morphology and aneuploidy. Nuclear lamins in cancer.