Lamin B2 Protein

It is the second of two type b nuclear lamins and it is associated with laminopathies.

Lamin b2 protein. View protein in smart sm01391 filament 1 hit. This protein too forms an aggregate in the absence of lamin b2. The antibody was incubated under agitation with protein g beads for 10min hela whole cell. You have reached your limit for free.

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding lys435 of human lamin b2 protein. However the structure of the nucleolus structure is affected 15. Lamin b2 nuclear envelope marker was immunoprecipitated using 0 5mg hela whole cell extract 5µg of mouse monoclonal to lamin b2 nuclear envelope marker ab8983 and 50µl of protein g magnetic beads. Lamin b2 is an important member of the lamin protein family encoded by lmnb2 which can selectively shear to form lamin b3 7 11 13 14.

The lamin family of proteins make up the matrix and are highly conserved in evolution. Abnormal recessive lethal study. View protein in interpro ipr018039 if conserved ipr039008 if rod dom ipr042180 if rod dom coil1b ipr001322 lamin tail dom ipr036415 lamin tail dom sf. View protein in smart sm01391 filament 1 hit.

Lamin b1 is a protein that in humans is encoded by the lmnb1 gene. Lmnb2 knockout mouse phenotype characteristic phenotype homozygote viability. The nuclear lamina consists of a two dimensional matrix of proteins located next to the inner nuclear membrane. As opposed to knockout in other lamins targeted lamin b2 knockout does not significantly change the nuclear fibril protein network.

No antibody was added to the control. Lamin a and c are cleaved by caspases into large 41 50 kda and small 28 kda fragments which can be used as markers for apoptosis 4 5. Vertebrate lamins consist of two types a and b. View protein in pfam pf00038 filament 1 hit pf00932 ltd 1 hit.

Lamin proteins are thought to be involved in nuclear stability chromatin structure and gene expression. Lamin b1 is also cleaved by caspases during apoptosis 9. View protein in pfam pf00038 filament 1 hit pf00932 ltd 1 hit. Lamin b2 is a protein that in humans is encoded by the lmnb2 gene.

Provided by refseq may 2012 other designations. Type b lamins consist of lamin b1 and b2 encoded by separate genes 6 8. Mutations in this gene are associated with acquired partial lipodystrophy. Lamin b2 epididymis secretory sperm binding protein lamin b3.