In immunolocalization studies the lamin a speckles or foci were found to colocalize with the rna splicing factors sc 35 and u5 116 kd but not with p80 coilin found in coiled bodies. Nuclear lamins e g lamin b1 produced from separate genes supplemental figure 2a. The nuclear lamina is composed mainly of type v intermediate filament proteins termed lamins which are classified into a and b type.
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