Lamin B1 Function

Specific for an epitope mapping between amino acids 559 586 at the c terminus of lamin b1 of mouse origin.

Lamin b1 function. Reacts with an epitope located c terminal of residue 231 in lamin b1. The nuclear lamina consists of a two dimensional matrix of proteins located next to the inner nuclear membrane. In mammalian cells nuclear structure and function are linked inextricably. However it is unknown whether structure is a fundamental determinant of function or a passive by product.

It is very good. Authors jordi camps 1 michael r erdos thomas ried. Ab8982 has been shown to react with hela and 3t3 cells in immunocytochemistry. Rated 5 out of 5 by q123 from the function is very good this lamin b1 is effective with strong band and low background.

Reacts against lamin b1 does not cross react with lamin b2. However rna seq after lamin b1 loss of function revealed significant enrichment of genes linked to migration and signaling in the genes upregulated after lamin b1 depletion suggesting a direct role of lamin b1 in the regulation of cell migration at the gene expression level. The major constituents of the nl are the type v intermediate filament proteins known as lamins which include lamins a c lamin b1 and lamin b2. Lamin b1 is a protein that in humans is encoded by the lmnb1 gene.

Nx p20700 lmnb1 lamin b1 function. Cells called oligodendrocytes which help coat nerve cells with myelin seem to be particularly affected. While lamin b1 is found in cells throughout the body it appears that cells in the brain are especially sensitive to changes in lamin b1. Other cell tissue types have not been tested.

Lamin b1 antibody b 10 is a mouse monoclonal igg 1 kappa light chain provided at 200 µg ml. Nucleoli undergo dramatic rearrangements during lamin b1 depletion. Increased lamin b1 activity leads to decreased expression of genes that are important for myelin function. Lamins are components of the nuclear lamina a fibrous layer on the nucleoplasmic side of the inner nuclear membrane which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.

Affiliation 1 a laboratory. Anti lamin b1 antibody b 10 is recommended for detection of lamin b1 of mouse rat and human origin by wb ip if and elisa. Lamins do not appear to be universally distributed among different cell and tissue types. The lamin family of proteins make up the matrix and are highly conserved in evolution.