Lamin B1 B2

Provided by refseq may 2012 other designations.

Lamin b1 b2. Lamin b1 is a protein that in humans is encoded by the lmnb1 gene. Lamin b1 is also cleaved by caspases during apoptosis 9. Reacts with an epitope located c terminal of residue 231 in lamin b1. Lamins do not appear to be universally distributed among different cell and tissue types.

Type b lamins consist of lamin b1 and b2 encoded by separate genes 6 8. Reacts against lamin b1 does not cross react with lamin b2. Lamin b1 is also cleaved by caspases during apoptosis 9. Tested in western blot wb immunofluorescence if and immunocytochemistry icc applications.

This antibody reacts with bovine human mouse rat samples. Other cell tissue types have not been tested. Lamin b1 항체 b 10 는 wb ip if 및 elisa 응용으로 m r 및 h lamin b1를 감지하는 단클론 anti lamin b1 항체이다. Lamin b2 epididymis secretory sperm binding protein lamin b3.

We found that deficiencies of either lamin b1 or lamin b2 cause nuclear membrane nm ruptures in migrating neurons accompanied by dna damage and cell death. Invitrogen anti lamin b1 b2 monoclonal x223 catalog ma1 5822. The lamin family of proteins make up the matrix and are highly conserved in evolution. Type b lamins consist of lamin b1 and b2 encoded by separate genes 6 8.

Our studies were informative because they uncovered large differences in the frequency. Lmnb2 knockout mouse phenotype characteristic phenotype homozygote viability. Deficiencies in lamin b1 or lamin b2 in mice result in markedly reduced neuronal density in the cerebral cortex but the mechanism has been unclear. Abnormal recessive lethal study.

The nuclear lamina consists of a two dimensional matrix of proteins located next to the inner nuclear membrane. Lamin a and c are cleaved by caspases into large 41 50 kda and small 28 kda fragments which can be used as markers for apoptosis 4 5. Lamin b2 is a protein that in humans is encoded by the lmnb2 gene. Lamin proteins are thought to be involved in nuclear stability chromatin structure and gene expression.

Ab8982 has been shown to react with hela and 3t3 cells in immunocytochemistry. Vertebrate lamins consist of two types a and b. They have been implicated in a wide variety of biological processes including cell adhesion differentiation migration signaling neurite outgrowth and metastasis. Lamin b1 antibodies.

Mutations in this gene are associated with acquired partial lipodystrophy. It is the second of two type b nuclear lamins and it is associated with laminopathies.