Lamin A C Molecular Weight

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Lamin a c molecular weight. Anti lamin a c antibody 636 is recommended for detection of lamin a and lamin c of mouse rat and human origin by wb ip if ihc p and fcm. Lamin a c is cleaved by caspase 6 and serves as a marker for caspase 6 activation. During apoptosis lamin a c is specifically cleaved into a large 41 50 kda and a small 28 kda fragment 3 4. Mouse monoclonal clone 4c11 anti lamin a c antibody is used to tag lamins a and or c for detection and quantitation by immunocytochemical and immunohistochemical ihc techniques such as immunoblotting immunoprecipitation and immunofluorescence.

Lamin a c is cleaved by caspase 6 and serves as a marker for caspase 6 activation. Laminins are high molecular weight 400 to 900 kda proteins of the extracellular matrix. Anti lamin a c antibody clone 2e8 2 antibody alexa fluor 488 conjugate. Lamin a consists of a central rod domain flanked by hydrophobic n and c terminal domains.

Lamin a is a 664 amino acid protein with a molecular weight of 70 kda calculated 74 139 da and a pi of 7 0 theoretical pi 7 4. The cleavage of lamins results in nuclear dysregulation and cell death 5 6. Cited in 81 publications. The ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately.

2000 j struct biol 129 313 23. During apoptosis lamin a c is specifically cleaved into a large 41 50 kda and a small 28 kda fragment 3 4. Raised against porcine lamin preparation. This antibody can recognize 4 isoforms of lamin a c.

The cleavage of lamins results in nuclear dysregulation and cell death 5 6. Bands are sharp at the correct molecular weight a bit of nonspecific signal at lower molecular weight but good resolution. This protein has 4 isoforms produced by alternative splicing with the molecular weight of 74 kda 65 kda 70 kda and 64 kda. The change in lmna molecular weight in the mutated hela cells is consistent with an in frame deletion.

2000 j struct biol 129 313 23. Lamin a c antibody e 1 is a monoclonal anti lamin a c antibody that is recommended for wb ip if ihc p and elisa.