Lamin A B C

Prelamin a c can accelerate smooth muscle cell senescence.

Lamin a b c. Prelamin a and lamin c differ in structure only at the carboxyl terminus. Vertebrate lamins consist of two types a and b. Lamin proteins are thought to be involved in nuclear stability chromatin structure and gene expression. Lamins a and c are alternatively spliced versions of the lmna gene.

During mitosis the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. During apoptosis lamin a c is specifically cleaved into a large 41 50 kda and a small 28 kda fragment 3 4. This gene encodes one of the two b type proteins b1. The lamin family of proteins make up the matrix and are highly conserved in evolution.

Lamin a c expression is a marker of mouse and human embryonic stem cell differentiation. The cleavage of lamins results in nuclear dysregulation and cell death 5 6. Dechat t gajewski a korbei b gerlich d daigle n haraguchi t et al. 2000 j struct biol 129 313 23.

It acts to disrupt mitosis and induce dna damage in vascular smooth muscle cells vsmcs leading to mitotic. Lamins are a class of intermediate filament proteins that form a matrix on the inner surface of the nuclear envelope. This creates a high amount of homology between the isoforms. Two isoforms lamins a and c can be created from this gene via alternative splicing.

Vertebrate lamins consist of two types a and b. These proteins are found in many different cell types in three different forms a b and c. Lamin proteins are thought to be involved in nuclear stability chromatin structure and gene expression. Lamin a c is cleaved by caspase 6 and serves as a marker for caspase 6 activation.

Lamin a c antibodies. Lamin a and c are present in equal amounts in the lamina of mammals. Nuclear lamin b is fragmented as a consequence of apoptosis by an unidentified member of the ice family. Lamins a and c are identical for the first 566 amino acids with lamin c differing only in six unique carboxy terminal amino acids.

Lamin b along with heterochromatin is anchored to the inner surface of the nuclear membrane by the lamin b receptor. Lamin c is a splice variant of lamin a differing only at the carboxy terminus.